inherited thrombophilia and recurrent pregnancy loss

conclusions: we determined a significant higher frequency of protein s deficiency in patients with rpl compared with controls. but the frequency of protein c deficiency and the frequency of two common thrombophilic mutations (factor v leiden and prothrombin g20210a), were not significantly different between patients with recurrent miscarriage and healthy women. results: the mean functional activity of protein c and protein s were not significantly different between case and control groups (p >0.05). frequency of protein c deficiency was also not significantly different between the case and control groups (p=0.906), but frequency of protein s deficiency was significantly higher in patients than controls (p=0.03). genotype pattern of the patients and healthy individuals were not significantly different with regard to either fvl or prothrombin g20210a (p > 0.05). patients and methods: the study group included 90 randomly selected patients with three or more consecutive miscarriages with the same partner in <20 weeks gestation in 2012. the control population consisted of 44 age-matched women with at least one live born children and no history of pregnancy loss. functional activity of protein c and s, activated protein c resistance, fvl assay by polymerase chain reaction and prothrombin gene mutation were assessed. the polymorphism frequencies were recorded for each group and comparisons were made. background: recurrent pregnancy loss (rpl) is a common health problem. the polymorphisms g20210a of prothrombin gene (fii g 20210a), and g 1691a of factor v gene (factor v leiden, fvl) are the most extensively studied thrombophilic mutations in association to recurrent miscarriage. objectives: to determine the frequency of fii g20210a and fvl polymorphisms as well as protein c and protein s deficiency in a series of patients with rpl compared with control group.